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Merkel cell carcinoma (mcc) is a rare and potentially aggressive neuroendocrine tumor of the skin, with a propensity for locoregional metastases. There was no bone marrow infiltration. Synaptophysin, chromogranin and cd56 are recommended markers to identify pulmonary tumors with neuroendocrine differentiation

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Whether the expression of these markers in pulmonary adenocarcinoma and pulmonary squamous cell carcinoma is a prognostic factor has been a matter of debate. The tumor cells were monomorphic round with fine chromatin, inconspicuous nucleoli, and moderate amount of eosinophilic cytoplasm. Immunohistochemical stains synaptophysin, chromogranin and ttf1 are positive in the tumor cells

These findings support the diagnosis of small cell neuroendocrine carcinoma of the lung.

Download scientific diagram | immunohistochemistry (ihc) showing tumor cells positive for synaptophysin (synaptophysin stain 400×) Here, we report a case of a typical carcinoid (tc) of the upper lobe of the left lung as well as the successful in vitro propagation and characterization of cancer stem cells out of the resected tumor tissue. On histopathological examination, there was a tumor in the left thyroid lobe that measured 0.4 cm Tumor immunohistochemical staining was positive for synaptophysin, chromogranin a.