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The trpv4 agonist gsk1016790a evoked ca 2+ signaling in muscularis macrophages, enteric glia, and endothelial cells This work further identifies muscularis macrophages as important players protecting the enteric nervous system against harmful events. The nervous system of the bowel regulates the inflammatory phenotype of tissue resident muscularis macrophages (mm), and in adult mice, enteric neurons are the main local source of colony stimulating factor 1 (csf1), a protein required for mm survival.
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In this review, we primarily focus on the interaction between the ens and mms in the muscularis externa of the gi tract We aimed to synthesize research that elucidates the current understanding of the influence of mms on enteric neurons and sip syncytium in the gi tract.
