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We also summarize the current knowledge of the dynamics of mirna action and of the secretion, transfer, and uptake of extracellular mirnas. Pirna, mirna, and sirna have in common their short length and ability to silence genes. Here, we summarize the current understanding of mirna biogenesis, function and regulation, and outline challenges to address in the future.

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Mirna biogenesis figure 1.mirna pathways the genes encoding mirnas are much longer than the processed mature mirna molecule