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There are three published studies of metformin in breast milk The results may be available soon. Some cohort data are available and randomised trials are currently in progress to compare metformin with insulin, but strong evidence is not yet available to guide management.

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Metformin is sometimes used as a galactogogue in women with reduced milk supply, but there is no evidence that it is effective The randomised metformin in gestational diabetes trial is currently underway to establish the efficacy of metformin compared with insulin, using neonatal outcome as a primary end point Metformin should be used with caution while nursing newborn and premature infants and those with renal impairment.

Research shows that metformin may also be taken with minimal effect on the baby

Sulphonylureas do get into breast milk to some degree, so there may be a risk that the baby’s blood glucose level will fall Of these, glibenclamide and glipizide appear to be the safest. Metformin, one of the most commonly prescribed medications for type 2 diabetes, is safe to take while breastfeeding Studies have shown that minimal amounts pass into breast milk, and levels in breastfed infants are equally tiny or undetectable, with no adverse effects.

Can metformin harm breastfed infants The amount of metformin that passes from breastfeeding mothers to their babies is not harmful Studies on the transfer of metformin into human milk found no adverse effects on breastfed infants.