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Despite its efficacy, iv iron administration carries the potential for adverse effects, with venous extravasation being a rare but notable complication This occurs when the iron solution leaks from the vein into the surrounding tissue, potentially. Venous extravasation occurs when an iv drug leaks out of the vein and into the surrounding tissue, leading to localized irritation, swelling, and sometimes tissue injury.

Sources of Iron

Skin staining occurs when there is extravasation or leakage of the infusion into the surrounding soft tissues The risk of extravasation injuries during iron infusion therapy iron infusions, such as ferinject, are often recommended for patients with low iron levels, particularly during pregnancy or after childbirth This clinical negligence case arose from an extravasation injury during an iron infusion

There was a failure to identify that the cannula had been incorrectly inserted

Consequently, the claimant suffered an extravasation injury in which the iron infusion leaked from the vein into the surrounding tissue This caused staining and ongoing pain and weakness in the claimant’s dominant right arm. Skin staining is an uncommon adverse effect that can occur with intravenous infusions if there is clear extravasation into the surrounding tissues, but also in the absence of obvious extravasation It has been reported with multiple iron preparations and doses.

5 iron staining can occur with intravenous infusions if there is extravasation into the surrounding tissue.